APhA Patient-Centered Diabetes Care 2025 – 400 Free Practice Questions to Pass the Exam

Thiazolidinediones, a class of medications used to manage type 2 diabetes, are associated with specific side effects that impact patients’ overall health. Weight gain and fluid retention are among the common side effects experienced by individuals using these medications.

These side effects occur due to the mechanism of action of thiazolidinediones, which enhance insulin sensitivity in muscle and adipose tissue but can also cause sodium retention. This sodium retention leads to fluid accumulation in the body, contributing to weight gain. Additionally, the increase in adipose tissue can also contribute to the overall weight gain observed in some patients.

The recognition of these side effects is essential for managing diabetes care effectively, as they may impact a patient's adherence to medication regimens and overall weight management strategies. Understanding the implications of these common side effects helps healthcare providers counsel patients appropriately and monitor for potential complications, fostering a more patient-centered approach to diabetes management.